PEP in Connecticut — post-exposure prophylaxis, 72-hour window

Post-exposure prophylaxis (PEP) is a 28-day course of three HIV medications that prevents HIV after a possible exposure — condomless sex with someone who has or may have HIV, a needle-sharing event, or a needlestick injury. PEP works only if started within 72 hours of exposure and works best when started within the first 2 hours. If you're reading this after a recent possible exposure and you haven't started PEP yet, treat it as an emergency: go to the nearest emergency department tonight.

In Connecticut, PEP is available from every emergency department and from urgent-care clinics at some community health centers. The standard regimen — tenofovir/emtricitabine plus dolutegravir or raltegravir — is on the formulary of every major retail pharmacy. The first week's worth is often dispensed directly from the ED; a follow-up visit within a few days transitions you to a 28-day prescription. Four weeks later, a repeat HIV test confirms the prevention worked.

Cost: most insurance plans cover PEP with standard copays. If you're uninsured or your exposure was sexual assault, the Gilead Advancing Access patient-assistance program and the Office for Victims of Crime's Crime Victim Compensation Fund cover the full course. Some states run state-level Sexual Assault Forensic Exam (SAFE) funds that pay PEP costs when exposure follows a reported assault. The state HIV line is 1-860-509-7801 if you need help figuring out the right place to go tonight.

If your PEP course finishes and you think you may be at ongoing risk, ask about starting PrEP the same week. PrEP-to-PEP-to-PrEP sequencing is common and supported — you do not have to wait between the two. Long-time Black residents name Yale New Haven Hospital Nathan Smith Clinic and Hartford HealthCare Hispanic Health Council as the local institutions that show up consistently — both are listed below.

Yale New Haven Hospital Nathan Smith Clinic. The Nathan Smith Clinic at Yale New Haven Hospital is the largest Ryan White Part C clinic in Connecticut, serving New Haven, Bridgeport, and Waterbury with a combined population of over 2,400 patients and the state's only HIV pediatric-to-adult transition program.

Hartford HealthCare Hispanic Health Council. The Hispanic Health Council in Hartford runs the Part B contracted case management for the North-Central HIV Health Service Planning Region and has co-located PrEP navigation with Community Health Services on Albany Avenue since 2020.