PrEP in Oklahoma — pre-exposure prophylaxis, who qualifies, how to start
The number
Oklahoma does not operate a state PrEP-DAP; the federal Ready, Set, PrEP program covers medication for eligible uninsured residents.
Ryan White Part B
Oklahoma State Department of Health, HIV/STD Service
State ADAP
Oklahoma HIV Drug Assistance Program
Income cap 300% FPL
State PrEP-DAP
Not operated; federal Ready Set PrEP applies
How to start PrEP in Oklahoma
Pre-exposure prophylaxis (PrEP) is a daily pill (Truvada, Descovy) or every-two-months injection (Apretude) that prevents HIV in people who don't have HIV. Taken as prescribed, daily-pill PrEP reduces the risk of sexually transmitted HIV by about 99% and the risk from injection-drug sharing by about 74%, per CDC. In Oklahoma, PrEP is available through primary-care providers, FQHCs, LGBTQ+ community health centers, and Ryan White Part C clinics — you do not need to see an HIV specialist to start.
To qualify for PrEP you need a recent negative HIV test (or one done the same day), a baseline labs panel (kidney function, hepatitis B, STIs), and a prescriber visit. Follow-up is every three months for a repeat HIV test and medication refill. Most insurance including Medicaid covers PrEP with zero out-of-pocket under the USPSTF Grade A preventive-services rule. The drug manufacturers (Gilead, ViiV) operate patient-assistance programs for anyone without insurance.
Oklahoma does not operate a state-funded PrEP Drug Assistance Program; residents rely on the federal Ready, Set, PrEP program (getyourprep.com) for medication coverage, Gilead Advancing Access or ViiV Connect for the drug copay, and the USPSTF Grade A preventive-services rule for clinic visits and labs (required zero-cost-share under the ACA). The state HIV program line is 1-405-271-4636 for a PrEP clinic referral.
Black PrEP uptake nationally lags sharply — a 2023 AIDSVu analysis found that Black Americans account for 42% of new HIV diagnoses but only 14% of PrEP users. Long-time Black residents name OU Health Infectious Diseases Institute and HOPE Community Services as the local institutions that show up consistently — both are listed below.
OU Health Infectious Diseases Institute. The OU Health Infectious Diseases Institute in Oklahoma City is the state's largest Ryan White Part C grantee, serving about 3,100 people living with HIV across Oklahoma; OU hosts the South Central AETC regional training program for HIV primary-care providers.
HOPE Community Services. HOPE Community Services in Oklahoma City is the Ryan White Part B case-management contractor for central Oklahoma, operating integrated HIV primary care on NW 23rd Street and a mobile testing van that rotates through the 73111 and 73106 zip codes that anchor Black HIV burden in the state.
For Black families in Oklahoma
The South carries the heaviest HIV burden in the country: Black Southern residents make up roughly 14% of the U.S. population but account for more than half of new Black HIV diagnoses nationally. PrEP uptake among Black Americans lags sharply — AIDSVu's 2023 PrEP-to-Need ratio analysis puts the Black PrEP ratio at roughly one-eighth the white ratio. In Oklahoma specifically, with 32% of new 2022 diagnoses among Black residents, closing that PrEP gap is the single highest-leverage prevention move. Black-led HIV organizations in the state run PrEP-specific navigation programs that match you with a prescriber, handle benefits coordination, and keep you in the three-month follow-up rhythm.
Named HIV testing + PrEP sites in Oklahoma
OU Health Infectious Diseases Institute
Oklahoma City, OK • 1-405-271-4000
HOPE Community Services — Oklahoma City
Oklahoma City, OK • 1-405-763-7794
H.O.P.E. Testing (Tulsa CARES)
Tulsa, OK • 1-918-834-4194
Where to get help in Oklahoma
- Oklahoma HIV info line: 1-405-271-4636 — staff can find the nearest free testing site, schedule PrEP, or help enroll you in ADAP.
- Oklahoma State Department of Health, HIV/STD Service landing page: https://oklahoma.gov/health/health-education/hivstd-service.html.
- Federally Qualified Health Centers in Oklahoma: every FQHC offers sliding-scale HIV testing and has certified application counselors on staff. See our FQHC directory for the state at /clinics/ok/.
- State health data for Oklahoma: for state-level HIV mortality, maternal health, and life-expectancy context by race, see /health/oklahoma/.
- Oklahoma Medicaid: Medicaid is the largest single payer of HIV care in most states. See /medicaid/oklahoma/ for eligibility + enrollment.
- Federal Ready, Set, PrEP: getyourprep.com — no-cost PrEP medication for people without insurance.
- CDC NPIN testing-site finder: gettested.cdc.gov accepts a zip code and returns every free + low-cost HIV testing site within 50 miles.
References & primary sources
- Oklahoma State Department of Health, HIV/STD Service: https://oklahoma.gov/health/health-education/hivstd-service.html.
- CDC HIV Surveillance Report 2022: cdc.gov/hiv/library/reports/hiv-surveillance.html. Source for state-level new diagnoses and race-stratified counts.
- HRSA HIV/AIDS Bureau, Ryan White HIV/AIDS Program grantee list: ryanwhite.hrsa.gov/grants/part-b.
- NASTAD ADAP Monitoring Project 2024 Annual Report: nastad.org/adap-monitoring-project. Source for ADAP income cap + enrollment + PrEP-DAP data.
- AIDSVu state profile: aidsvu.org/state/oklahoma/.
- CDC PrEP guidelines, 2021 update: cdc.gov/hiv/clinicians/prevention/prep.html.
Data refreshed: