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Glossary

U=U (Undetectable = Untransmittable)

Also known as: Undetectable equals Untransmittable

Medically reviewed, last updated

U=U is the scientific consensus that a person living with HIV who has a sustained undetectable viral load (under 200 copies/mL) cannot sexually transmit HIV to partners. Endorsed by CDC, NIH, and over 1,000 organizations worldwide. The evidence base includes the PARTNER, PARTNER2, and Opposites Attract studies covering 130,000+ acts of condomless sex among serodiscordant couples with zero linked transmissions.

U=U materially changes HIV care: treatment IS prevention. For Black communities navigating both HIV stigma and PrEP access gaps, U=U is the single most important destigmatizing fact about HIV in 2026.

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Medical Disclaimer

This glossary entry is for informational and educational purposes only. It is not a substitute for professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider with questions about a medical condition.