PEP in South Dakota — post-exposure prophylaxis, 72-hour window

Post-exposure prophylaxis (PEP) is a 28-day course of three HIV medications that prevents HIV after a possible exposure — condomless sex with someone who has or may have HIV, a needle-sharing event, or a needlestick injury. PEP works only if started within 72 hours of exposure and works best when started within the first 2 hours. If you're reading this after a recent possible exposure and you haven't started PEP yet, treat it as an emergency: go to the nearest emergency department tonight.

In South Dakota, PEP is available from every emergency department and from urgent-care clinics at some community health centers. The standard regimen — tenofovir/emtricitabine plus dolutegravir or raltegravir — is on the formulary of every major retail pharmacy. The first week's worth is often dispensed directly from the ED; a follow-up visit within a few days transitions you to a 28-day prescription. Four weeks later, a repeat HIV test confirms the prevention worked.

Cost: most insurance plans cover PEP with standard copays. If you're uninsured or your exposure was sexual assault, the Gilead Advancing Access patient-assistance program and the Office for Victims of Crime's Crime Victim Compensation Fund cover the full course. Some states run state-level Sexual Assault Forensic Exam (SAFE) funds that pay PEP costs when exposure follows a reported assault. The state HIV line is 1-800-592-1861 if you need help figuring out the right place to go tonight.

If your PEP course finishes and you think you may be at ongoing risk, ask about starting PrEP the same week. PrEP-to-PEP-to-PrEP sequencing is common and supported — you do not have to wait between the two. Long-time Black residents name Sanford Health Infectious Disease Clinic (Sioux Falls) and Falls Community Health (Sioux Falls) as the local institutions that show up consistently — both are listed below.

Sanford Health Infectious Disease Clinic (Sioux Falls). Sanford Health's ID Clinic in Sioux Falls is South Dakota's only HIV specialty clinic and Ryan White Part C grantee, covering the entire state through a combination of in-person and telehealth appointments, with a dedicated outreach partnership with the Great Plains Tribal Leaders Health Board.

Falls Community Health (Sioux Falls). Falls Community Health is South Dakota's largest FQHC, operating the only walk-in rapid-HIV-testing program in the state with evening hours, and providing HIV primary care for patients transferring out of the state Department of Corrections system.