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Clinical interactions & pharmacogenomics

Drug interaction checker

Enter up to four medications. The tool checks every pair against a curated library sourced from FDA labels and CPIC Guidelines, and flags pharmacogenomic differences that matter for Black patients (CYP2C19, CYP2D6, VKORC1, ADRB2).

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Data sources: FDA labels, CPIC Guidelines, ACC/AHA & ADA guidelines.

Pharmacogenomics for Black patients (1)

  • Albuterol

    ADRB2

    The ADRB2 Arg16Gly polymorphism affects beta-2 receptor sensitivity. The Arg/Arg genotype is more common in Black patients and has been associated with reduced response to regular albuterol and, with chronic use, worse asthma control.

    What this means for Black patients: Guidelines now favor ICS-containing rescue inhalers (SMART / MART with budesonide/formoterol) over SABA-only rescue, especially in Black patients, partly because of ADRB2 pharmacogenomics.

    Source: GINA 2024 Pocket Guide. Wechsler ME et al. Lancet 2009.

Always talk to your pharmacist. This tool is educational and only surfaces interactions we can cite. Pharmacy software checks every combination in your full medication regimen against continually-updated databases like Lexicomp and Micromedex, use this tool to sharpen the questions you bring to that conversation, not to replace it.

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