Skip to main content
Black Health logo Black Health

Clinical interactions & pharmacogenomics

Drug interaction checker

Enter up to four medications. The tool checks every pair against a curated library sourced from FDA labels and CPIC Guidelines, and flags pharmacogenomic differences that matter for Black patients (CYP2C19, CYP2D6, VKORC1, ADRB2).

Your medications

Start typing for suggestions.

Start typing for suggestions.

Start typing for suggestions.

Start typing for suggestions.

Reset

Data sources: FDA labels, CPIC Guidelines, ACC/AHA & ADA guidelines.

Pharmacogenomics for Black patients (1)

  • Clopidogrel

    CYP2C19

    Clopidogrel is a prodrug activated by CYP2C19. Loss-of-function (LOF) variants reduce activation and raise stent thrombosis and cardiovascular event rates. Allele frequency is higher in patients of African ancestry — roughly 40% carry at least one LOF allele vs. ~25% in European populations — and the CYP2C19*2 allele is the most common LOF variant across groups.

    What this means for Black patients: Genotype-guided prescribing (CPIC Guideline 2022) recommends testing before starting clopidogrel after PCI, especially in Black patients. When LOF variants are present, ticagrelor or prasugrel is preferred.

    Source: Lee CR et al. Clin Pharmacol Ther 2022;111:959–967. CPIC Guideline for CYP2C19 and Clopidogrel.

Always talk to your pharmacist. This tool is educational and only surfaces interactions we can cite. Pharmacy software checks every combination in your full medication regimen against continually-updated databases like Lexicomp and Micromedex, use this tool to sharpen the questions you bring to that conversation, not to replace it.

Related resources