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Clinical interactions & pharmacogenomics

Drug interaction checker

Enter up to four medications. The tool checks every pair against a curated library sourced from FDA labels and CPIC Guidelines, and flags pharmacogenomic differences that matter for Black patients (CYP2C19, CYP2D6, VKORC1, ADRB2).

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Data sources: FDA labels, CPIC Guidelines, ACC/AHA & ADA guidelines.

Pharmacogenomics for Black patients (1)

  • Fluoxetine

    CYP2D6 / CYP2C19

    Fluoxetine is metabolized by CYP2D6 and CYP2C19. Ultra-rapid CYP2C19 metabolizers clear fluoxetine too quickly; poor metabolizers of either enzyme accumulate the drug. Because fluoxetine itself inhibits CYP2D6, it also amplifies this interaction for other CYP2D6 substrates.

    What this means for Black patients: Sertraline is generally preferred for first-line SSRI therapy when drug-drug interactions are a concern.

    Source: CPIC SSRI Guideline 2023.

Always talk to your pharmacist. This tool is educational and only surfaces interactions we can cite. Pharmacy software checks every combination in your full medication regimen against continually-updated databases like Lexicomp and Micromedex, use this tool to sharpen the questions you bring to that conversation, not to replace it.

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