Clinical interactions & pharmacogenomics
Drug interaction checker
Enter up to four medications. The tool checks every pair against a curated library sourced from FDA labels and CPIC Guidelines, and flags pharmacogenomic differences that matter for Black patients (CYP2C19, CYP2D6, VKORC1, ADRB2).
Pharmacogenomics for Black patients (1)
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Paroxetine
CYP2D6Paroxetine is both a substrate and a strong inhibitor of CYP2D6. Poor metabolizers experience higher plasma levels and more side effects; the phenotype distribution differs by ancestry.
What this means for Black patients: Sertraline or escitalopram are preferred SSRIs in Black patients because they are less CYP2D6-dependent and less likely to interact with commonly-used drugs (metoprolol, tramadol, tamoxifen).
Source: CPIC SSRI Guideline 2023.
Always talk to your pharmacist. This tool is educational and only surfaces interactions we can cite. Pharmacy software checks every combination in your full medication regimen against continually-updated databases like Lexicomp and Micromedex, use this tool to sharpen the questions you bring to that conversation, not to replace it.