CYP2D6
Cytochrome P450 2D6
What it does
Metabolizes codeine, tramadol, tamoxifen, many antidepressants and antipsychotics. Phenotype ranges from poor to ultrarapid metabolizer.
Why this matters for Black patients
African-ancestry populations carry the *17 variant (intermediate metabolism) at much higher frequencies than European populations. This affects efficacy of codeine, tamoxifen, and several SSRIs.
Common variants
| Variant | Phenotype | African | European |
|---|---|---|---|
| *17 | Intermediate metabolizer | 0.200 | 0.005 |
| *4 | Poor metabolizer | 0.050 | 0.200 |
| *xN | Ultrarapid metabolizer (duplications) | 0.050 | 0.010 |
Note: This page is reference information, not medical advice. Pharmacogenomic differences are about ancestry, not race; race is an imperfect proxy. Discuss any medication changes with your prescriber.