SLCO1B1
Solute Carrier Organic Anion Transporter Family Member 1B1
What it does
Transporter that controls statin uptake into liver.
Why this matters for Black patients
SLCO1B1 *5 is the major risk variant for simvastatin-associated myopathy. Its frequency is lower in African ancestry than European, which means generic dosing recommendations may overestimate risk.
Common variants
| Variant | Phenotype | African | European |
|---|---|---|---|
| *5 | Decreased function | 0.020 | 0.160 |
Note: This page is reference information, not medical advice. Pharmacogenomic differences are about ancestry, not race; race is an imperfect proxy. Discuss any medication changes with your prescriber.