PEP in Wyoming — post-exposure prophylaxis, 72-hour window
The number
PEP prevents HIV only if started within 72 hours of exposure; every emergency department in Wyoming carries it on formulary.
Ryan White Part B
Wyoming Department of Health, Communicable Disease Unit
State ADAP
Wyoming AIDS Drug Assistance Program
Income cap 300% FPL
State PrEP-DAP
Not operated; federal Ready Set PrEP applies
Accessing PEP in Wyoming — the 72-hour window
Post-exposure prophylaxis (PEP) is a 28-day course of three HIV medications that prevents HIV after a possible exposure — condomless sex with someone who has or may have HIV, a needle-sharing event, or a needlestick injury. PEP works only if started within 72 hours of exposure and works best when started within the first 2 hours. If you're reading this after a recent possible exposure and you haven't started PEP yet, treat it as an emergency: go to the nearest emergency department tonight.
In Wyoming, PEP is available from every emergency department and from urgent-care clinics at some community health centers. The standard regimen — tenofovir/emtricitabine plus dolutegravir or raltegravir — is on the formulary of every major retail pharmacy. The first week's worth is often dispensed directly from the ED; a follow-up visit within a few days transitions you to a 28-day prescription. Four weeks later, a repeat HIV test confirms the prevention worked.
Cost: most insurance plans cover PEP with standard copays. If you're uninsured or your exposure was sexual assault, the Gilead Advancing Access patient-assistance program and the Office for Victims of Crime's Crime Victim Compensation Fund cover the full course. Some states run state-level Sexual Assault Forensic Exam (SAFE) funds that pay PEP costs when exposure follows a reported assault. The state HIV line is 1-307-777-7953 if you need help figuring out the right place to go tonight.
If your PEP course finishes and you think you may be at ongoing risk, ask about starting PrEP the same week. PrEP-to-PEP-to-PrEP sequencing is common and supported — you do not have to wait between the two. Long-time Black residents name Wyoming Health Council and Cheyenne Regional Medical Center Infectious Disease Clinic as the local institutions that show up consistently — both are listed below.
Wyoming Health Council. The Wyoming Health Council in Casper is the state's Ryan White Part B case-management contractor, operating rapid testing at six clinic sites across Natrona, Laramie, and Fremont counties and the state's only dedicated HIV peer-navigation program.
Cheyenne Regional Medical Center Infectious Disease Clinic. The ID Clinic at Cheyenne Regional Medical Center is Wyoming's primary HIV specialty clinic and Ryan White Part C grantee, covering eastern Wyoming through a telehealth partnership with the University of Colorado's Denver Health ID Clinic.
For Black families in Wyoming
Black patients are less likely to be offered PEP in the emergency department than white patients with comparable exposures, per published ED-utilization research. If you're in Wyoming and you show up at an ED within 72 hours of a possible exposure, advocate for yourself: ask specifically for 'HIV post-exposure prophylaxis' and the infectious-diseases consult. The community organizations listed below can also coordinate a same-day PEP dispense at their clinic in most metros.
Where to get help in Wyoming
- Wyoming HIV info line: 1-307-777-7953 — staff can find the nearest free testing site, schedule PrEP, or help enroll you in ADAP.
- Wyoming Department of Health, Communicable Disease Unit landing page: https://health.wyo.gov/publichealth/communicable-disease-unit/hivaids/.
- Federally Qualified Health Centers in Wyoming: every FQHC offers sliding-scale HIV testing and has certified application counselors on staff. See our FQHC directory for the state at /clinics/wy/.
- State health data for Wyoming: for state-level HIV mortality, maternal health, and life-expectancy context by race, see /health/wyoming/.
- Wyoming Medicaid: Medicaid is the largest single payer of HIV care in most states. See /medicaid/wyoming/ for eligibility + enrollment.
References & primary sources
- Wyoming Department of Health, Communicable Disease Unit: https://health.wyo.gov/publichealth/communicable-disease-unit/hivaids/.
- CDC HIV Surveillance Report 2022: cdc.gov/hiv/library/reports/hiv-surveillance.html. Source for state-level new diagnoses and race-stratified counts.
- HRSA HIV/AIDS Bureau, Ryan White HIV/AIDS Program grantee list: ryanwhite.hrsa.gov/grants/part-b.
- NASTAD ADAP Monitoring Project 2024 Annual Report: nastad.org/adap-monitoring-project. Source for ADAP income cap + enrollment + PrEP-DAP data.
- AIDSVu state profile: aidsvu.org/state/wyoming/.
- CDC PEP guidelines, non-occupational exposure: cdc.gov/hiv/clinicians/prevention/pep.html.
Data refreshed: