Drug class
Used for
Chlorthalidone
Thiazide-type diureticBrand: Thalitone
Chlorthalidone has the strongest outcome evidence of any first-line antihypertensive in Black adults. The ALLHAT trial randomized 15,094 Black participants and found …
View guideFurosemide
Loop diureticBrand: Lasix
Furosemide itself has no major race-specific efficacy signal, it works through a transporter (NKCC2) that is not genetically variable in ways relevant …
View guideHydrochlorothiazide
Thiazide diureticBrand: Microzide, HCTZ
Thiazide-type diuretics are guideline-preferred first-line agents for Black adults with uncomplicated hypertension (2017 ACC/AHA, Whelton et al., 2018). Importantly, however, leading hypertension …
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