Drug class
Used for
Fluoxetine
SSRIBrand: Prozac, Sarafem
Fluoxetine is primarily metabolized by CYP2D6 (with contributions from CYP2C9 and 3A4). CYP2D6 allele distributions vary by ancestry, but variant effects on …
View guideParoxetine
SSRIBrand: Paxil, Pexeva, Brisdelle
Paroxetine is a potent CYP2D6 inhibitor and is itself metabolized by CYP2D6. This creates pharmacokinetic complexity that is not specifically race-differential but …
View guideSertraline
SSRI (selective serotonin reuptake inhibitor)Brand: Zoloft
SSRIs as a class have more complex race-specific evidence than cardiovascular drugs. Three themes matter:Response rates. Post-hoc analyses of STAR*D (Lesser et …
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